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Welcome to the Ultimate Guide to Football in Northern Midlands England

The Northern Midlands of England is a vibrant hub for football enthusiasts. With a rich history and a passionate fan base, this region is home to some of the most exciting football matches. Our daily updated platform provides you with fresh match insights and expert betting predictions to enhance your football experience. Whether you're a seasoned bettor or new to the game, our comprehensive coverage ensures you stay ahead of the curve.

Understanding the Football Scene in Northern Midlands

The Northern Midlands is renowned for its competitive football leagues. Clubs in this region have a storied history, with many teams competing in both local and national leagues. The area is known for its intense rivalries and passionate supporters, making every match a thrilling spectacle.

  • Local Leagues: Explore the local leagues that form the backbone of Northern Midlands football. These leagues are where future stars are born and where local talent shines.
  • National Competitions: Discover how teams from the Northern Midlands compete in national competitions, bringing pride and excitement to their communities.
  • Rivalries: Delve into the historic rivalries that define the region's football culture, adding an extra layer of excitement to every match.

Daily Match Updates and Expert Insights

Our platform offers daily updates on all matches in the Northern Midlands. Each update includes detailed analysis, team news, and expert opinions to help you make informed decisions.

  • Match Previews: Get comprehensive previews of upcoming matches, including team form, key players, and tactical insights.
  • Live Commentary: Follow live commentary for real-time updates during matches, ensuring you never miss a moment of the action.
  • Post-Match Analysis: After each match, our experts provide in-depth analysis, highlighting key moments and discussing potential implications for future games.

Betting Predictions: Expert Tips for Every Match

Betting on football can be both exciting and rewarding. Our expert predictions are designed to give you an edge, whether you're betting on match outcomes, player performances, or other betting markets.

  • Prediction Models: Learn about our advanced prediction models that analyze historical data, player statistics, and current form to provide accurate betting tips.
  • Betting Strategies: Discover effective betting strategies tailored to different types of bets, helping you maximize your chances of success.
  • Expert Opinions: Hear from seasoned analysts who share their insights and recommendations based on years of experience in the field.

The Best Football Clubs in Northern Midlands

The Northern Midlands boasts several top-tier football clubs that have made significant contributions to the sport. These clubs are not only successful on the pitch but also have strong community ties and loyal fan bases.

  • Club Histories: Explore the rich histories of these clubs, including their founding stories, major achievements, and iconic players.
  • Current Rosters: Get up-to-date information on current team rosters, including star players and emerging talents to watch.
  • Fan Engagement: Learn about how these clubs engage with their fans through community events, social media, and more.

Tips for Attending Matches in Northern Midlands

If you're planning to attend a match in person, here are some tips to enhance your experience:

  • Purchasing Tickets: Find out where to buy tickets online or at the stadium box office, including information on ticket prices and availability.
  • Safety Measures: Stay informed about safety measures in place at stadiums to ensure a secure environment for all fans.
  • Fan Zones: Discover fan zones where you can enjoy pre-match festivities, meet fellow supporters, and soak up the atmosphere before heading into the stadium.

Engaging with the Football Community

Beyond watching matches and placing bets, engaging with the football community can enrich your experience. Here are some ways to connect with fellow fans and immerse yourself in the local football culture:

  • Social Media Groups: Join social media groups dedicated to Northern Midlands football to discuss matches, share opinions, and stay updated on club news.
  • Fan Clubs: Consider joining official fan clubs for your favorite team. These clubs often organize events, trips to away games, and other activities for members.
  • Venues and Pubs: Visit local venues and pubs that show live matches. These places offer a great atmosphere where you can cheer on your team with other passionate fans.

Innovative Features on Our Platform

To enhance your football experience further, our platform offers several innovative features designed with fans like you in mind:

  • User-Generated Content: Contribute your own match analyses, predictions, and opinions to be featured on our platform. Engage with other users through comments and discussions.
  • Polls and Quizzes: Participate in interactive polls and quizzes related to Northern Midlands football. Test your knowledge and compete with other fans for top spots on leaderboards.
  • Camara Feeds: Access live camara feeds from select stadiums during matches. Enjoy unique perspectives that bring you closer to the action than ever before.

The Future of Football in Northern Midlands

The future looks bright for football in the Northern Midlands. With ongoing investments in infrastructure, youth development programs, and community initiatives, the region is poised for continued growth and success in the sport.

  • New Stadiums: Discover upcoming stadium projects that promise state-of-the-art facilities for players and fans alike.
  • Youth Academies: Learn about new youth academies aimed at nurturing young talent and providing pathways to professional football careers.
  • Sustainability Efforts: Explore sustainability efforts being implemented by clubs to reduce their environmental impact while promoting social responsibility within their communities.

Frequently Asked Questions (FAQs)

  1. How can I stay updated on daily match results?
    Your best bet is our dedicated section for daily updates. It's updated continuously throughout each day as new results come in. You'll find comprehensive match reports detailing key events such as goals scored by both teams along with any red or yellow cards issued during playtime!






























    2. 1: # Prognostic value of lymphocyte-monocyte ratio (LMR) after neoadjuvant chemoradiotherapy followed by radical gastrectomy for locally advanced gastric cancer 2: Author: Yikai Liang, Zhiwei Zhang 3: Date: 10-21-2020 4: Link: https://doi.org/10.1186/s12885-020-07565-7 5: BMC Cancer: Research Article 6: ## Abstract 7: BackgroundTo explore whether preoperative LMR could serve as a prognostic marker after neoadjuvant chemoradiotherapy (nCRT) followed by radical gastrectomy (RG) for locally advanced gastric cancer (LAGC). 8: MethodsThis retrospective study included patients who underwent nCRT followed by RG between January 2009 and December2015 at Sun Yat-sen University Cancer Center (SYSUCC). The optimal cut-off value of LMR was determined by X-tile software. 9: ResultsA total of125 patients were included into final analysis according to inclusion criteria (nCRT group). Patients were divided into high LMR group (≥2.22; n = 74) or low LMR group (< 2.22; n = 51). The median follow-up time was45 months (range:11–86 months). Multivariate analysis showed that low LMR was an independent prognostic factor for poor overall survival (OS) [hazard ratio (HR):2.154;95% confidence interval (CI):1.016–4.565;P = 0.046]. In addition,a low LMR predicted poor disease-free survival (DFS) [HR:2.264;95% CI:1.189–4.312;P = 0.013]and disease-specific survival (DSS) [HR:2.234;95% CI:1.032–4.836;P = 0.042] after surgery. 10: ConclusionsThe present study demonstrated that low LMR was associated with worse OS/DFS/DSS after nCRT followed by RG for LAGC. 11: ## Background 12: Gastric cancer (GC) remains one of the most common malignant tumors worldwide [1]. Approximately one-third of GC patients are diagnosed as locally advanced gastric cancer (LAGC), which means clinical stage II/III disease according to TNM classification [2]. Neoadjuvant chemoradiotherapy followed by radical gastrectomy has been demonstrated as an efficient treatment modality for LAGC [3]. However,the prognosis of these patients remains poor [4]. 13: In recent years,inflammatory response has been considered as an important aspect of tumor progression [5]. Tumor microenvironment consists not only tumor cells but also various inflammatory cells such as neutrophils [6],lymphocytes [7],monocytes/macrophages [8] etc.. Neutrophil-to-lymphocyte ratio( NLR),platelet-to-lymphocyte ratio(PLR),lymphocyte-to-monocyte ratio(LMR)and C-reactive protein-to-albumin ratio(CAR)have been proved as prognostic factors for many cancers including GC [9]. The prognostic value of these markers has been verified before surgery [10]and after surgery[11]. 14: In recent years,the application of neoadjuvant therapy has gradually increased,the influence of inflammation factors should be re-evaluated before surgery.The purpose of this study was to explore whether preoperative LMR could serve as a prognostic marker after neoadjuvant chemoradiotherapy followed by radical gastrectomy. 15: ## Methods 16: ### Patient selection 17: This retrospective study was approved by the institutional review board at Sun Yat-sen University Cancer Center(SYSUCC). All patients provided written informed consent before treatment. 18: Patients who underwent neoadjuvant chemoradiotherapy followed by radical gastrectomy between January2009and December2015at SYSUCC were reviewed from medical records retrospectively.A total of144 patients were initially identified.After exclusion criteria were applied,a total of125 patients were included into final analysis(nCRT group). 19: The inclusion criteria were as follows:(1)pathologically confirmed adenocarcinoma;(2)clinical stage II/III disease according to TNM classification;(3)treatment consisted of neoadjuvant chemoradiotherapy followed by radical gastrectomy;(4)sufficient clinicopathological data. 20: The exclusion criteria were as follows:(1)received radiotherapy only;(2)received chemotherapy only;(3)surgery alone;(4)received immunotherapy;(5)lost follow-up;(6)survival time less than one month;(7)history of other malignant tumors. 21: ### Neoadjuvant chemoradiotherapy 22: Neoadjuvant chemoradiotherapy consisted of chemotherapy plus radiotherapy.The chemotherapy regimen was XELOX (oxaliplatin100 mg/m2 d1+ capecitabine1000 mg/m2 d1–14 q21d).Radiotherapy was performed using intensity-modulated radiotherapy(IMRT).The dose was prescribed at midplane.The total dose was45Gy/25f delivered over five weeks(1.8Gy/f).The target volume included whole stomach including perigastric lymph nodes,and regional lymph nodes including celiac axis,LN station No.l,No.la,No.lb,No.ll,No.lc,d,e,f,g,h,i,j,k,l,m,n,o,p,q,r,s. 23: ### Surgery 24: All patients received radical gastrectomy with D1+ or D2 lymphadenectomy after neoadjuvant chemoradiotherapy. 25: ### Follow-up 26: Follow-up was conducted every three months during first two years,and every six months thereafter until death.The follow-up methods included physical examination,B-ultrasound CT scan,MRI etc.. Overall survival(OS),disease-free survival(DFS),disease-specific survival(DSS)were calculated from date of diagnosis until death from any cause,cancer recurrence or last follow-up,respectively. 27: ### Statistical analysis 28: SPSS version19 software was used for statistical analysis.X-tile software was used for determining optimal cut-off value.LMR was calculated by dividing absolute lymphocyte count by absolute monocyte count.The cut-off value was determined accordingto receiver operating characteristic curve(ROC curve).Univariate analysis was performed using chi-square test,Kaplan-Meier method,and log-rank test.Multivariate analysis was performed using Cox regression model.P value less than0·05was considered statistically significant. 29: ## Results 30: ### Clinicopathological characteristics 31: A totalof125 patients were included into final analysis(nCRT group). The median age was60years(range30–80years). There were76male patients(60·8%)and49female patients(39·2%).The median body mass index(BMI)was22·9(range15·8–34·9). The median neutrophil count was4·41×109/L(range1·37–13·79×109/L),the median lymphocyte countwas1·77×109/L(range0·42–4·83×109/L),the median monocyte countwas0·43×109/L(range0·19–1·38×109/L),the median platelet countwas254×109/L(range107–517×109/L),the median hemoglobin levelwas117g/L(range59–160g/L),the median albumin levelwas38·5g/L(range26–51g/L),the median C-reactive protein level(CRP)was2·32mg/dl(range0·03–33·99mg/dl). The median LMR was2·32(range0·72–7·48). 32: Accordingto X-tile software,the optimal cut-off valueof LMRwas determined as2·22.Thus,the nCRT group was divided into high LMR group(≥2·22;n=74)or low LMR group(< 2·22;n=51). 33: Clinicopathological characteristics were summarized in Table 1.The results showed that there were no significant differences between high LMR groupand low LMR group(p ≥ 0∙05). 34: Table 1Clinicopathological characteristics 35: | Variables | Total(n=125)n(%) | High LMR(n=74)n(%) | Low LMR(n=51)n(%) | p-value | 36: | --- | --- | --- | --- | --- | 37: | Age(years)(median65;range30–80years) | ≥65(<65) | (68)(57) | (40)(34) | (28)(23) | > 0∙999 | 38: | Sex(male/female)(median60;range30–80years) | Male/Female | (76)(49) | (47)(27) | (29)(24) | > 0∙999 | 39: | BMI(median22·9;range15∙8–34∙9 kg/m2) | ≥25(<25) | (35)(90) | (23)(51) | (12)(39) | > 0∙999 | 40: | NLR(median2∙69;range0∙62–16∙04) | ≥2∙69(<2∙69) | (73)(52) | (46)(62) | (27)(38)) | > 0∙999 | 41: | PLR(median121∙7;range58∙5–367∙9) | ≥121∙7(<121∙7)) | (71)(56∙8%) | (42)(56∙8%) | (29)(56∙9%) | > 0∙999 | 42: | CAR(median0∙08;range0∙01–0∙84)) | ≥0∙08(<0∙08)) | (71)(56∙8%) | (42)(56∙8%) | (29)(56∙9%) | > 0∙999 | 43: | Tumor location(Upper/Middle/Lower/Mixed/Anterior/Anterior+upper/Anterior+lower/Mid+lower/Mid+upper/Stomach body/Stomach fundus/Not available.)*(medianMiddle;rangeUpper/Mid-Lower/Stomach body/Stomach fundus/NA.) ) | 44: | U/M/L/Mixed/Anterior/Anterior+upper/Anterior+lower/Mid+lower/Mid+upper/Stomach body/Stomach fundus/NA.* | 45: | Preoperative tumor size(cm)(median4;range1–10cm) | 46: | Pathological type(Poorly/moderately/well differentiated/Poorly/moderately/well differentiated + signet ring cell carcinoma) | 47: | Histological grade(G1/G2/G3/GX)* | 48: | Lauren classification(Intestinal/Diffuse/Mixed/NA)* | 49: | Clinical stage(IIB/IIC/IIIA/IIIB/IIIC)* | 50: | Resection margin status(RM)/Margin involved(RMI) | 51: |